Technology

The initial NDT product is a complete test platform.  This system includes a unique instrument based upon our patented biosensor technology and novel disposable assay cassette, specific for each biomarker target.

BIOSENSOR

The NDT instrument is built with our unique patented biosensor.

FEATURE

BENEFIT
25 detector diodes Multiplex capable
Wide Dynamic Light Intensity Range Ultra sensitive

  • 250k photons/second
  • Not as susceptible to whiteout
Wide Dynamic Light-wavelength Range Fine tuning unnecessary
Dynamic Read capability Scheduled sampling

  • Qualitative results
  • Quantitative results

 

INSTRUMENT

  • Small footprint
  • Chemiluminescence or fluorescence
  • Low cost
  • Easy to use

 

FEATURE

BENEFIT
Simple operation Highly trained laboratory personnel are not required
Quick ~ 2 minute read time
Scalable Short read time facilities batch testing where necessary
Portable, lightweight, small footprint Easy to move around
Functional and flexible Can test a broad range of pathogens
Objective results Not subjective – no guessing at the answer
Exceptional Value Low cost of ownership

 

CASSETTE

Our novel cassette and assay have been developed to appropriately manage sample, assay, and the chemiluminescent reaction.  The design facilitates ease of use and minimizes operator testing error.

 

 

REFERENCES

Vo-Dinh, T., J. P. Alarie, et al. (1999). “DNA biochip using a phototransistor integrated circuit.” Anal Chem 71(2): 358-363.

Stokes, D. L., G. D. Griffin, et al. (2001). “Detection of E. coli using a microfluidics-based antibody biochip detection system.” Fresenius J Anal Chem 369(3-4): 295-301.

Song Joon, M. and T. Vo-Dinh (2002). “Integrated CMOS microchip system with capillary array electrophoresis.” Anal Bioanal Chem 373(6): 399-403.

Askari, M. D., G. H. Miller, et al. (2002). “Simultaneous detection of the tumor suppressor FHIT gene and protein using the multi-functional biochip.” Cancer Detect Prev 26(5): 331-42.

Stratis-Cullum, D. N., G. D. Griffin, et al. (2003). “A miniature biochip system for detection of aerosolized Bacillus globigii spores.” Anal Chem 75(2): 275-80.
Lanciotti, R. S., A. J. Kerst, et al. (2000).

“Rapid detection of west nile virus from human clinical specimens, field-collected mosquitoes, and avian samples by a TaqMan reverse transcriptase-PCR assay.” J Clin Microbiol 38(11): 4066-71.
van de Vijver, M. J., Y. D. He, et al. (2002).

“A gene-expression signature as a predictor of survival in breast cancer.” N Engl J Med 347(25): 1999-2009.
Culha, M., D. Stokes, et al. (2003).

“Surface-enhanced Raman scattering for cancer diagnostics: detection of the BCL2 gene.” Expert Rev Mol Diagn 3(5): 669-75.
Kasili, P. M., J. M. Song, et al. (2004).

“Optical sensor for the detection of caspase-9 activity in a single cell.” J Am Chem Soc 126(9): 2799-806.
Culha, M., D. L. Stokes, et al. (2004).

“Application of a miniature biochip using the molecular beacon probe in breast cancer gene BRCA1 detection.” Biosens Bioelectron 19(9): 1007-12.

Askari, M. D. and T. Vo-Dinh (2004). “Implication of mitochondrial involvement in apoptotic activity of fragile histidine triad gene: application of synchronous luminescence spectroscopy.” Biopolymers 73(4): 510-23.
Vo-Dinh, T. (2002).

“Nanobiosensors: probing the sanctuary of individual living cells.” J Cell Biochem Suppl 39: 154-61.
Moreno-Bondi, M. C., J. P. Alarie, et al. (2003).

“Multi-analyte analysis system using an antibody-based biochip.” Anal Bioanal Chem 375(1): 120-4.